| K014: How Do Antarctic Fishes Use Antifreeze to Survive in Ice-laden Water? |
Clive EvansUniversity of AucklandHow supercooled fishes utilise anti-freeze glycoproteins (AFGPs) to survive in freezing Antarctic waters is an outstanding biological problem resolvable through the combination of biology and synthetic organic chemistry. We propose to chemically synthesise non-radioactively labelled AFGPs and to use the products to track the route by which secreted anti-freeze is able to reach high levels in the circulation, to identify the cell type involved in ice crystal entrapment, and to characterise the likely receptor.
Website linksInvestigation of the role of anti-freeze glyco-proteins in the circulation system of Antarctic fish |